We identify 519 locus-metabolite associations for 427 metabolite peaks and validate our findings in two multi-ethnic cohorts. Here, we perform a whole genome association study of 2,291 metabolite peaks (known and unknown features) in 2,466 Black individuals from the Jackson Heart Study. In addition, these analyses have principally involved known metabolites, with the majority of the profiled peaks left unannotated. However, gene-metabolite integration has been primarily studied in individuals of European Ancestry, limiting the opportunity to leverage genomic diversity for discovery. Integrating genetic information with metabolomics has provided new insights into genes affecting human metabolism. Nature Communications volume 13, Article number: 4923 ( 2022) NHLBI Trans-Omics for Precision Medicine 1 Consortium,.He died in Paris.Whole Genome Association Study of the Plasma Metabolome Identifies Metabolites Linked to Cardiometabolic Disease in Black Individuals As remarked by Sir Archibald Geikie, the doctrine of the origin of valleys by the erosive action of the streams which flow through them was first clearly taught by Desmarest.Īn enlarged and improved edition of his map of the volcanic region of Auvergne was published after his death, in 1823, by his son Anselme Gaëtan Desmarest (1784-1838), who was distinguished as a zoologist, and author of memoirs on recent and fossil crustaceans. He then pointed out the succession of volcanic outbursts and the changes the rocks had undergone through weathering and erosion. It was not, however, until 1774, that he published an essay on the subject, accompanied by a geological map, having meanwhile on several occasions revisited the district. In 1763 he made observations in Auvergne, recognizing that the prismatic basalts were old lava streams, comparing them with the columns of the Giant's Causeway in Ireland, and referring them to the operations of extinct volcanoes. He utilized his journeys, travelling on foot, so as to add to his knowledge of the Earth's structure. This attracted much attention, and ultimately led to his being employed in studying and reporting on manufactures in different countries, and in 1788 to his appointment as inspector-general of the manufactures of France.
Buffon's Theory of the Earth interested him, and in 1753 he successfully competed for a prize by writing an essay on the ancient connection between England and France.
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Taking full advantage of the instruction he received, he was able to support himself by teaching, and to continue his studies independently. Of humble parentage, he was educated at the College of the Oratorians of Troyes and Paris. ĭesmarest was born in Soulaines, in the department of Aube. Nicolas Desmarest (16 September 1725 – 20 September 1815) was a French geologist and contributor to the Encyclopédie ou Dictionnaire raisonné des sciences, des arts et des métiers, in particular, the multi-volume Géographie-physique.
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